Niger Delta Medial Journal

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EFFECT OF SERUM 25-HYDROXYCHOLECALCIFEROL (VITAMIN D) LEVELS ON GLYCEMIC CONTROL IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN BENIN CITY

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Authors: Ekiye Ayinbuomwan , Alphonsus N. Onyiriuka
Department of Chemical Pathology, University of Benin Teaching Hospital,
Benin City , Edo State.

Endocrinology and Metabolism Unit, Department of Child Health, University of
Benin Teaching Hospital, Benin City, Edo State.
Correspondence
Ekiye AYINBUOMWAN
Department of Chemical Pathology,
University of Benin Teaching Hospital, Benin City, Edo State.
ekiyeayinbuomwan@gmail.com
https://orcid.org/ 0000-0003-8044-2471

ABSTRACT
BACKGROUND: Vitamin D is known to play a role in the homeostasis of blood glucose therefore regular
assessment is important in Type 1 Diabetes Mellitus (DM) patients to rule out deficiency.
OBJECTIVE: To determine the relationship between serum vitamin D levels and glycemic control in
children with Type1 DM.
METHODS: A cross-sectional study of all patients with Type 1 DM on insulin therapy who attended the
Pediatric Outpatients’ Clinic, University of Benin Teaching Hospital, Benin City, Nigeria between May
2019 and December 2020. Participants in the study consisted of 26 T1DM patients recruited via
convenient sampling and 20 controls who were apparently well non-diabetic children. Both groups were
between ages 1- 18years. Blood samples were collected before and after ninety days of vitamin D
administration (400 IU daily) from the patients for estimation of vitamin D and glycated hemoglobin
(HbA1c) while controls had only one sample collected for analysis and received no form of treatment.
RESULTS: A total of 26 patients with T1DM were studied along with 20 controls and 3.8% of the
patients had vitamin D insufficiency while the controls were all vitamin D sufficient. The mean
concentration of HbA1c was lower post-vitamin D administration though not statistically significant (P =
0.13). The estimated average blood glucose (eAG ) before vitamin D administration, was significantly
higher than the post-vitamin D eAG levels (P= 0.04). There was no significant change in vitamin D levels
in the patients (66.16 ± 1.26nmol/L pre and 67.54 ±1.23nmol/L post vitamin D administration) ( P = 0.41).
CONCLUSION: The percentage of patients with vitamin D insufficiency in this study was 3.8% while
none of the controls had insufficiency. The drop in HbA1c after vitamin D supplementation , though not
significant could suggest a possible role of vitamin D in glycemic control in patients with TIDM.
KEY WORDS: Glycemic control, Glycated Hemoglobin, Type 1 Diabetes Mellitus, Vitamin D.